Artificial Intelligence (AI) is poised to be the most transformative technology of this, or perhaps any, generation in American history. To capture this opportunity for the American People, the Artificial Intelligence and Technology Office (AITO) developed the following strategic operating model, or Program Plan. This plan evolves prior year activity, concentrating on a department-wide, cross- cutting portfolio alignment of AI investments to maximize impacts. In addition, the Program Plan leverages strategic partnerships, particularly the National Artificial Intelligence Initiative Office (NAIIO) and international relationships, as central enablers of AI outcomes and impacts that exemplify the mission of the administration and Department of Energy (DOE). Successful implementation of this plan will provide national leadership in AI tools, technologies, policies, and emerging capabilities in FY 23 and beyond.