The second workshop in the Data Science and Artificial Intelligence Regulatory Applications Workshops series is intended to provide an overview of current NRC and industry initiatives to expand and apply data science and AI, including early-stage project development and research to solve ongoing issues. Topics in the second workshop will focus on enabling regulatory transformation to increase efficiency, leveraging publicly available data sources such as the agency’s document management system ADAMS, and highlighting current projects which may influence regulatory decision-making, provide alternative approaches to traditional analyses, or are seeking to optimize industry efficiency.