Robotics and AI used to stabilize enzyme that reduces scar tissue, increases tissue regeneration

Researchers at Rutgers University working on U.S. National Science Foundation grants have stabilized an enzyme that can reverse and regenerate tissue damage from spinal cord injuries. Using artificial intelligence and robotics, the team formulated therapeutic proteins that help repair damaged spinal cord tissue. The scientists published their research in Advanced Healthcare Materials.

ChABC, the enzyme the team stabilized, is volatile and has a short shelf life under clinical conditions. The compound can repair scar tissue molecules and promote regeneration, but the logistics and expense of multiple high-cost infusions have limited its efficacy. Stabilizing ChABC is key to developing affordable and functional therapeutic applications.

“This study represents one of the first times artificial intelligence and robotics have been used to formulate highly sensitive therapeutic proteins and extend their activity by such a large amount,” said Adam Gormley, the principal investigator. “The therapy may someday help people lessen scars on their spinal cords and regain function.

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